Gen Zed does NOT have the claim of being the first to have a transgender woman as a main character.
Do you guys remember Maddie Blaustein?
MADDIE BLAUSTEIN.
She was a transwoman voice actress who did work between 1997-2008 which was probably before these SJWs were born. She died in 2011 from a stomach virus.
While she mostly did side characters mostly from 4Kids, her most famous role was Meowth.
Meowth who was in almost every episode.
Meowth who you could also credit as a main character, certainly a male antagonist who was every bit as loved as a member of Team Rocket. (Come on, guys. You can’t tell me no one liked Team Rocket. I loved the heck out of Team Rocket as a kid.)
She was also known for having a large vocal range. Meowth, Lezard, Yugi’s grampa, Arngrim. She wasn’t just a one-voice actress.